Can I use Osmo Masterpiece to create large drawings?

The Masterpiece drawing area is about the size of standard printer paper (8.5x11 or an A4). You can draw on a larger area by drawing on the visible area, moving the paper and reference, then realigning it. This technique will allow you to draw on whatever size you want to, but it's a bit advanced and still only lets you focus on one area at a time.